منابع مشابه
Synthetic gene networks that count.
Synthetic gene networks can be constructed to emulate digital circuits and devices, giving one the ability to program and design cells with some of the principles of modern computing, such as counting. A cellular counter would enable complex synthetic programming and a variety of biotechnology applications. Here, we report two complementary synthetic genetic counters in Escherichia coli that ca...
متن کاملGene Silencing Repeats that Count
RIP is nucleus limited. We know this because the specialized cells that carry out RIP are heterokaryotic, with nuclei from both parents. When a sequence is duplicated in one nucleus but not the other, the lone copy is never silenced. The mechanism of RIP is unknown but probably involves DNA:DNA pairing (Figure 1) followed by methyla-Repeated DNA and cytosine methylation are common tion and deam...
متن کاملPaper-Based Synthetic Gene Networks
Synthetic gene networks have wide-ranging uses in reprogramming and rewiring organisms. To date, there has not been a way to harness the vast potential of these networks beyond the constraints of a laboratory or in vivo environment. Here, we present an in vitro paper-based platform that provides an alternate, versatile venue for synthetic biologists to operate and a much-needed medium for the s...
متن کاملApplications of synthetic gene networks.
Synthetic gene networks have evolved from simple proof-of-concept circuits to complex therapy-oriented networks over the past 15 years. This advancement has greatly facilitated the expansion of the emerging field of synthetic biology. In this review, we highlight the main applications ofsynthetic gene networks in understanding biological design principles, developing biosensors for diagnosis, p...
متن کاملEngineering of synthetic mammalian gene networks.
Synthetic biology, the science of engineering complex biological systems with novel functions, is increasingly fascinating researchers across disciplines who gather to design functional biological assemblies in a rational and systematic manner. Although initial success stories were based on reprogramming prokaryotic and lower eukaryotic cells, the design of synthetic mammalian gene circuits is ...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1172005